
HDL (Good Cholesterol)
through the bloodstream in particles called lipoproteins. The fatty substance in lipoproteins include cholesterol and triglycerides, which we should add are the most common fatty substance in the human body. The proteins that combine with fats to produce lipoproteins are called apolipoproteins, often abbreviated apo.
intestinal cells assemble from the proteins and fats you consume at the dinner table. Chylomicrons are very, very low density particles. In cholesterol jargon the lower the density the more dangerous. These tiny particles start out with almost no protein and a lot of light and feathery fat and cholesterol. As they flow through your bloodstream from your intestines on their way to your liver, the chylomicrons release their fats, known as triglycerides, into your blood. This stripped down chylomicron, also known as a chylomicron remnant, still contains cholesterol and protein. At this point, the remnant slides into your liver and fat comes back into the picture. If you have every had a chance to evaluate foods that are high in fat you know liver is right at the top of every list. In fact a 3 oz portion of beef liver has an astonishing 330 mg of cholesterol. As you now know, your liver is a veritable fat and cholesterol factory that collects fat fragments from your blood and uses them to make cholesterol and new fats that your body can use to build tissue and perform other physiological functions. When our friendly chylomicron hits the liver, its picks up fat particles and mutates into the largest kind of lipoprotein. This virtual fat and cholesterol bomb is called a VDLD or very low density lipoprotein. From the liver our friendly artery clogging VDLD makes it way out into the bloodstream. In its travels it drops large amounts of fat, picks up large amounts of cholesterol, and changes into a slightly smaller, heavier particle called an intermediate low density lipoprotein or IDL, and then a slightly smaller, heavier low density lipoprotein (LDL). The last step in our chylomicrons evolution occurs when an LDL has dropped so much fat and cholesterol into body tissue that it’s now becomes mostly protein. After all that we finally arrive with what is considered good cholesterol or HDL. Why are HDLs considered to be good cholesterol
make good health sense to have as much HDL hanging around as possible but what is the reason behind this assumption? The fact is that our friendly HDLs don’t carry cholesterol into our arteries because they’re so compact and so dense that they can’t squeeze through the spaces in the walls of our arteries. As a result, HDLs and their payload of cholesterol travel away from the arteries and toward the flashing neon exit sign, and then out of the body in form of solid waste. It is probably fair to categorize HDLs as scavenger molecules that remove cholesterol from the arteries. Having large numbers of HDLs traveling through the system is a heart healthy formula for reducing the risk of heart attack and stroke regardless of how high your total cholesterol might be. Recent X-ray studies have shown that people who raise their HDLs by exercising, putting the kibosh on cigarette smoking, consuming HDL boosting foods, or taking medications or supplements to reduce overall cholesterol levels have a good chance of seeing a markedly decrease in dangerous arterial plaque. Are all LDLs bad?
most doctors classify LDL as bad and that having large numbers of light and fluffy LDLs capable of squeezing through your artery walls and leaving a present of fat deposited is considered a giant negative in reducing the risk of heart attack.
of LDLs floating through their system seem to be able to avoid a coronary event. Was it simply good luck or something more? Researchers exploring longevity ran various tests on 213 senior citizens plus 216 of their children and grandchildren. For comparison, they ran the same tests on a control group of non blood relatives, such as the children’s husbands and wives. What the tests revealed was a surprise to everyone: The seasoned citizens were three times more likely than other people to have a mutation in a gene that regulates cholesteryl ester transfer protein (CETP), an enzyme that influences the size of lipoproteins. As a result, compared with other people, including those non related husbands and wives, even the seasoned citizens who had high levels of LDLs had relatively larger low density lipoproteins. It is important to point out that their HDLs (good cholesterol) molecules were also larger. The study concluded that the level of LDLs doesn’t necessarily predict heart disease. It is the size of the LDLs that is the ultimate determiner of risk. Put in another way, having many small LDLs may raise the risk of heart attack even if your overall cholesterol level is low. LDL and HDL ranges LDL: Less than 100 mg/dl optimal; 100 – 129 near optimal; 130 – 159 borderline high; 160 -189 high; 190 and above dangerously high HDL: Over 60 optimal; 40 – 59 borderline to poor; below 40 dangerously low Heart healthy ratios for HDL and LDL As well as heart healthy ranges there are also some ratios worth mentioning, that of total cholesterol to HDL and HDL to LDL. Cholesterol to HDL: Lowest risk of heart attack 3.8 and below for women and 2.9 and below for men; low risk of heart attack 3.9 – 4.7 for women and 3 – 3.6 for men; moderate 4.9 -5.9 for women and 3.7 to 4.6 for men; high risk 6.0 - 6.9 for women and 4.7 – 5.6 for men; and finally over 7.0 for women and above 5.7 is the high risk category. There also is the ratio between LDL (bad cholesterol) and HDL (good cholesterol). Most cardiologist recommend that you have no more than twice as much LDL and HDL. This number is suggest for people with no family or previous history of cardiovascular disease. If you do have a history of cardiovascular disease or have two or more know risk factors (age, smoking, obesity, high stress levels) for coronary artery disease then the ratios tighten up a bit with 1 HDL for every 1.4 LDL molecules being the suggested ratio.
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